Disease-Associated miRNA-mRNA Networks in Oral Lichen Planus
نویسندگان
چکیده
منابع مشابه
Disease-Associated miRNA-mRNA Networks in Oral Lichen Planus
BACKGROUND A large number of pathophysiological mechanisms are regulated by microRNAs (miRNAs), which represent a new class of posttranscriptional regulators of gene expression. To date, little is known about their role in oral lichen planus (OLP), a chronic inflammatory mucocutaneous disease of unknown etiology which is being discussed as a potentially premalignant condition of oropharyngeal c...
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Background: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. Objective: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. Methods: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were...
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Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma. Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP. Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides oppo...
متن کاملOral lichen planus.
Physical examination There were multiple ulcerations over the lower lip (Figure 1). The gingiva was swollen and inflamed (Figure 1). Lace-like whitish streaks and well-defined Date: 13 March, 2002 Venue: Yaumatei Dermatology Clinic Organizer: Social Hygiene Service, DH; Clinico-pathological Seminar whitish plaques were found on the lower lip, gingiva and the left buccal mucosa (Figures 1& 2). T...
متن کاملOral lichen planus.
Reticular LP is usually asymptomatic, affects multiple sites, and can be recognized by white papules that can coalesce to form plaques. There may be fine, white, lace-like striae (Wickham striae) on the buccal mucosa, gingiva, and lips. Cutaneous LP may be seen in up to 44% of patients with oral LP. Erosive LP usually presents with pain while eating, especially with spicy foods. There is usuall...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0063015